Then, we compared the 354 mRNAs with 425 significantly deregulated proteins in the EIF3B silencing group and identified 8 common genes, namely, VIM, TEF, CALB2, MVD, ASS1, GDF15, NDRG1 and CEBPB (Fig. 4A), and their expression results are shown in Fig. 4B. Then, we examined studies on the oncogenic and tumor-suppressing roles of the 8 genes in HNSCC and finally chose CEBPB as a target candidate. The gene discussed is GDF15; the disease is head and neck squamous cell carcinoma.