MTHFD1L and pancreatic neoplasm: In this study, we screened the differentially expressed circRNAs in human pancreatic cancer cell lines and gemcitabine resistant pancreatic cancer cell lines through circRNA sequencing technology, cross-screened with data from the authoritative public database GEO, and discovered a new gemcitabine resistant-related molecule in pancreatic cancer: hsa_circ_0078297 (circ-MTHFD1L).