TNF and cancer: Among the 8974 genes with significant variance in gene expression (p-adjust < 0.001, differential folds > 1.3), the Top10 KEGG pathways involved in the differential gene expression caused by knockout of CDK6 are intimately related to advanced glycation end product (AGE)-AGE receptor (AGE-RAGE) signaling, transforming growth factor-β signaling, endocrine resistance (acquired drug resistance to endocrine therapy of cancers), tumor necrosis factor signaling, et al., among which CDK6 is one of the top10 factors (Fig. 3A).