Among the 8974 genes with significant variance in gene expression (p-adjust < 0.001, differential folds > 1.3), the Top10 KEGG pathways involved in the differential gene expression caused by knockout of CDK6 are intimately related to advanced glycation end product (AGE)-AGE receptor (AGE-RAGE) signaling, transforming growth factor-β signaling, endocrine resistance (acquired drug resistance to endocrine therapy of cancers), tumor necrosis factor signaling, et al., among which CDK6 is one of the top10 factors (Fig. 3A). Here, CDK6 is linked to cancer.