In this study, to evaluate the effect of genetic and epigenetic factors involved in this disease, VEGF, IGF1, IGF2 and H19 lncRNA genes expression and epigenetic alterations of H19-DMR regulatory region in endometrial tissues of 12 patients with endometriosis and 12 normal women (as control) were assessed. The gene discussed is IGF1; the disease is endometriosis.