In AD patients, cognitive impairment progression was found to be related to Th17 cells and c-Jun N-terminal kinase (JNK) pathway-associated phosphatase (JKAP), the latter play a key role in regulating inflammation and immune responses; JKAP and Th17 cells were dysregulated and inter-correlated in AD [95]. This evidence concerns the gene MAPK8 and Alzheimer disease.