BACE1 and serum lipopolysaccharide activity: In male SD rats injected intraperitoneally with LPS, the use of IL-17A-neutralizing antibodies inhibited the expression of APP and Beta-site APP-cleaving enzyme 1 (BACE1), and prevented the expression of TNF-α, IL-6 and inflammatory proteins, indicating the role of anti-IL-17A strategy in the treatment of endotoxemia-induced neuroinflammation and cognitive dysfunction [65].