SNCA and Parkinson disease: Liu et al. used rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S), a nano-scavenger for clearing α-synuclein aggregates in neurons, as a platform for PD treatment, and they found that REXO-C/ANP/S could achieve immune activation clearing by inhibiting Th17 and enhancing Treg to regulate the immune system in mice with PD [120].