In the present study, the GAPDH inhibitory effect, which were assumed to be due to HA, was confirmed in transplanted tumors by HA administration in vivo, as seen in Fig. 2B. This strongly suggests that orally administered HA passes through the gut, is circulated in the bloodstream, reaches the transplanted tumors, and inhibits tumor growth in vivo. This evidence concerns the gene GAPDH and neoplasm.