Diverse mechanisms and pathways are controlled by the anti-melanoma activity of natural bioactive nutrients, like increased apoptosis, caspase activity, and expression of p53- and Bcl-2-associated X (bax), and also the inhibition of angiogenesis and tumor-promoting proteins, showing the complexity and importance of natural compounds in the chemoprevention and therapy of murine malignant melanoma. This evidence concerns the gene TP53 and neoplasm.