In another study, [8], biflavonoid amentoflavone was described as a compound that possesses pro-apoptotic effect in murine melanoma cells, an effect related to a mechanism with the G0/G1 to S phase arrest, p21, p27, p53, bcl-2 Bax and caspase-3 and -9 protein regulation. The gene discussed is BAX; the disease is melanoma.