Herein, we proposed light-activated monomethyl auristatin E (MMAE) prodrug nanoparticles, constructed with photosensitizer chorin e6 (Ce6), caspase-3-specific cleavable KGDEVD peptide, and a chemotherapeutic drug (MMAE) for combinational photo-chemotherapy of pancreatic cancer. The gene discussed is CASP3; the disease is familial pancreatic carcinoma.