In total, environmental factors that induce skin carcinogenesis via AhR activation include: (a) ultraviolet radiation (UVR), which is associated with the majority of melanoma cases (65%) as well as with almost all other skin cancer cases (90%) including BCC and SCC [67], given the fact that partial mediation of ultraviolet radiation damage became through the photochemical intracellular production of the potent AhR ligand (FICZ) [6,18,21], (b) carcinogenic chemicals in air pollutants as TCDD, and (c) metabolites of Malassezia yeast implicate in extramammary Paget’s disease (EMPD) [68]. This evidence concerns the gene AHR and melanoma.