In a mouse model of myocardial ischemia, the levels of potential lipid mediators, including eicosanoids and lysophospholipids were altered in PNPLA8-deficient and PNPLA8-overexpressing mice, suggesting that PNPLA8 also has a function in the production of these lipid mediators [98]. This evidence concerns the gene PNPLA8 and myocardial ischemia.