Moreover, the SQ called micheliolide (MCL) alleviated hepatic steatosis in the db/db mouse model by inhibiting inflammation and lipid accumulation in lipid mixture-induced AML12 and L02 cells by upregulating PPARγ and decreasing phosphorylation of IκBα and NF-κB/p65, inhibiting NF-κB (Table 1). The gene discussed is NFKB1; the disease is fatty liver disease.