CXCL8 and edema: SQ lactones from Neurolaena lobate (Asteraceae) inhibited lipopolysaccharide (LPS) and TNF production, interfered with the production of E-selectin and interleukin-8 (IL-8) in HUVECtert and THP-1 cells, and inhibited the development of acute inflammation in carrageenan-induced paw edema in rats [59].