PRRT2 and hepatocellular carcinoma: It was mechanically reported that daphnetin has inhibitory activity on a variety of protein kinases, such as EGFR, PKA, and PKC, with IC50 values of 7.67 μM, 9.33 μM, and 25.01 μM, respectively [43], and also inhibition of the survival of hepatocellular carcinoma cells through regulating the Wnt/β-catenin signaling pathway [47].