Extensive GABAergic remodeling is apparent in AD, but the cation–chloride cotransporters (CCCs) K-Cl-2 (KCC2) and N-K-Cl-1 (NKCC1) have also been implicated in disease progression by altering GABA signaling polarity in several neurological disorders [17]. This evidence concerns the gene SLC12A2 and Alzheimer disease.