The isoform-1 of multimerin-1 (MMRN1) and leucine-rich α-2-glycoprotein (LRG1) were identified as highly expressed, while S100 calcium-binding protein A8 (S100A8), serpin B3 (SERPINB3) and a cluster of differentiation-44 antigen (CD44) were significantly downregulated in the urine of CC patients [167]. Here, SERPINB3 is linked to cholangiocarcinoma.