ACHE and memory impairment: A considerable increase in the level of AChE in the brain homogenate was observed after STZ administration (Table S4 and Figure 3), which was effectively reversed by the donepezil, metformin, and extracts (p < 0.05, p < 0.01, p < 0.001), signifying the pharmacological function of extracts in treatment of memory impairment, probably via ChE inhibition.