CCND1 and sarcoma: Further, 102 purified from the EtOAc soluble fraction of the root extract of tissue cultured P. indica induced apoptosis and suppressed sarcoma-180 cancer cell proliferation, alongside G1 cell cycle arrest through cyclin D1, Bcl-2, and Ki-67 down-regulation, revealing its apoptotic and antiproliferative capacities versus sarcoma-180 solid tumor in vivo in mice [61].