To answer this question, we took the 16 TFs displaying the largest centrality differences between the healthy and COVID-19 networks of the same cell types (FOXP1, STAT3, ATF3, STAT1, SMAD3, ETS1, ETV6, BHLHE40, SPI1, NFKB1, IRF1, RUNX1, MEF2C, RARA, FOS, CREB5) for further analysis. The gene discussed is STAT3; the disease is COVID-19.