To answer this question, we took the 16 TFs displaying the largest centrality differences between the healthy and COVID-19 networks of the same cell types (FOXP1, STAT3, ATF3, STAT1, SMAD3, ETS1, ETV6, BHLHE40, SPI1, NFKB1, IRF1, RUNX1, MEF2C, RARA, FOS, CREB5) for further analysis. This evidence concerns the gene SMAD3 and COVID-19.