CHMP5 and infection: For this, at least six different mechanisms have been described that increase the efficiency of infection by SARS-CoV-2 VOCs and are directly related to mutations in the Spike protein (Figure S5): (1) increasing hACE2 affinity (KD) and (2) extending the time the Spike protein remains bound to hACE2, thus increasing the likelihood that Spike is cleaved by proteases and proceeds to membrane fusion.