Considering the expression of CD86 on monocytes, Carter, M.J. et al. have shown reduced CD86 expression together with elevated levels of IL-1β, IL-6, IL-8, IL-10, IL-17 and IFN-γ in children with multisystem inflammatory syndrome (MIS-C) associated with SARS-CoV-2 infection [54]. The gene discussed is IL10; the disease is COVID-19–associated multisystem inflammatory syndrome in children.