Such a proinflammatory microenvironment, although it might stimulate viral clearance through the activation of phagocytic cells [69], could also favor cellular transformation since the activation of the IL6/JAK/STAT3 axis could favor the appearance and the development of hepatocellular carcinoma (HCC), breast, and ovarian cancers [15,70,71,72]. Here, STAT3 is linked to hepatocellular carcinoma.