In conclusion, clustering PLWH according to canonical patterns of CSF AD biomarkers did not detect any HIV-specific association; the inter-relationship between amyloid and tau proteins seem to differ from that observed in AD subjects and although the main driver of alterations in CSF tau proteins seem represented by non-specific inflammation within the CNS, the mechanisms underlying the rare isolated BA42 consumption remain unclear. Here, MAPT is linked to Alzheimer disease.