According to our previous study [23] that suggested the potential clinical utility of quantifying plasma sTNFR2 levels for diagnosing acute ATL, we further validated the diagnostic value of sTNFR2 by comparison to other putative ATL biomarkers (sCD25, sOX40, and IL-10) in plasma and PVL. The gene discussed is IL10; the disease is periventricular leukomalacia.