IFITM1 and neuroblastoma: The IFITM protein family was first discovered in 1984 by a cDNA screen of IFN-stimulated neuroblastoma cells [12] and currently consists of five members in humans (IFITM1, 2, 3, 5, and 10), of which only IFITM1, 2, and 3 have been identified as potent inhibitors of virus entry [13,14].