CD40LG and viral infectious disease: Fattal et al. [31] and Westergaard et al. [32] studied the response to anti-EBNA1 IgA, IgM and IgG antibodies of individuals with autoimmune disease, finding normal, similar, or even reduced titers compared to healthy controls, pointing out that the humoral immune response is dysregulated against EBV infection is conditioned to the lytic phase of viral infection among patients with autoimmune disease, which corroborates our findings regarding the high frequency of viral DNA visualized in the plasma of individuals.