Although we still observed the significant decrease of activity of Renilla luciferase by using WSN-PB2 KO/Rluc virus infection without PB2, this demonstrates that KAP1-PB2 interaction may just play a role in the influenza life cycle and KAP1 affects the viral replication through multiple aspects such as innate immune response and posttranslational modification as shown in Figure 6 and Figure 7. Here, TRIM28 is linked to viral infectious disease.