IFI16 and infection: Then, two studies found that during infection by HSV-1 (in HFF cells), KSHV (in human B lymphoma cells (BJAB- EBV-negative Burkitt’s lymphoma cell line)—or HMVEC-d) or EBV (in BJAB, latency and HMVEC-d cells), the IFI16 was bound to genomes in complex with H2B histone and with the BRCA1 protein.