In a study of Lin et al. [42], 631 patients with chronic HBV, APRI and fibrosis 4 score-index (FIB-4 = age (year) × AST [U/L]/(platelets [109/L] × (ALT [U/L])1/2 were compared for the diagnosis of significant fibrosis and cirrhosis. Here, GPT is linked to Cirrhosis.