CHMP5 and infection: Previously, we identified a pan-CoV fusion inhibitor, EK1, which can interact with the HR1 trimer in many HCoV spike proteins and block homologous viral 6-HB fusion core formation, thus demonstrating its efficacy in inhibiting fusion and infection of SARS-CoV, MERS-CoV, SARS-CoV-2, and other HCoVs [10].