To further clarify the effect of FR on tenogenesis in tendinopathy, we detected the transcriptional levels of tendon forming factors (Dcn, Scx, Mkx and Tnmd) and found that FR effectively reversed the mRNA expression of Dcn, Scx, Mkx and Tnmd in mice with tendinopathy (Figure 1G–J). This evidence concerns the gene TNMD and disease of the tendon.