DNA methylation change of 15 imprinted genes induced by HFD feeding was observed, including Magel2, Ctnna3, Gab1, and L3mbtl1, that are reported to be linked to the pathogenesis of obesity, high cognitive processes in adulthood, circadian machinery, and growth and development of embryos (Supplementary Table S5) [32,33]. The gene discussed is L3MBTL1; the disease is Obesity.