In the ConvR HFD-LS group, 9 genes DNA methylation changes including Atg4c, Ldlr, Scarb1, and Ankrd11 were related to obesity, and 6 genes DNA methylation changes including Zmiz1, Pde7b, Litaf, and Maf were related to T2D (Supplementary Tables S2 and S3). The gene discussed is LDLR; the disease is obesity due to melanocortin 4 receptor deficiency.