In ConvR HFD mice liver, 17 genes DNA methylation changes including Ube2l3, Etv5, Lrp1, and Nudt3 were determined related to obesity and 11 genes DNA methylation changes including Exoc312, Mst1r, Prkch, and Arhgap26 were determined related to Type 2 diabetes (T2D) in the previous study. The gene discussed is UBE2L3; the disease is type 2 diabetes mellitus.