In diabetic islets, adipose, or liver tissue, genes (Exoc3l2, Mst1r, Prkch, Arhgap26, Itga3, Pde7b, Litaf, Galnt10, Zmiz1) DNA methylation changes were identified to be associated with T2D [53,60,61]. The gene discussed is PDE7B; the disease is type 2 diabetes mellitus.