In ConvR HFD mice liver, 17 genes DNA methylation changes including Ube2l3, Etv5, Lrp1, and Nudt3 were determined related to obesity and 11 genes DNA methylation changes including Exoc312, Mst1r, Prkch, and Arhgap26 were determined related to Type 2 diabetes (T2D) in the previous study. This evidence concerns the gene UBE2L3 and obesity due to melanocortin 4 receptor deficiency.