IDH3A and Hyperglycemia: Moreover, the observation that the activities of aconitase and isocitrate dehydrogenase were more reduced by resveratrol in diabetic platelets compared with platelets of healthy people, indicates that, in hyperglycemia, resveratrol also reduced platelet function by the reduction of oxidative metabolism and energy production (Table 1 and Table 2, Figure 1 and Figure 2).