INS and Hyperglycemia: Therefore, increased platelet aggregation, TXA2 production, TBARS accumulation, or elevated activities of hexokinase and G-6-P dehydrogenase may reflect the megakaryocytes and blood platelet metabolic adaptive up-regulation of enzymes responsible for glucose utilization, possibly via an insulin-independent Glut3 transporter, leading to platelet hyperactivation observed in hyperglycemia (Table 1 and Table 2, Figure 1, Figure 2 and Figure 3).