Induction of the nuclear factor kappa B (NF-kB) pathway is known to play a very important role in the pathophysiology of Dox-mediated kidney inflammation [50], with NF-kB being a transcription factor that regulates expression of several genes associated with inflammation [51], such as those encoding TNF-α, IL-1β, and IL-6 [52,53]. This evidence concerns the gene TNF and nephritis.