After adjusting for age, gender, diabetes, Alb, Hb, Hs-CRP, and neutrophil/lymphocyte ratio, AID (adjusted HR = 1.85, 95% CI: 1.01–3.39, p = 0.04, Table 3) and HIS (adjusted HR = 2.70, 95% CI: 1.39–5.25, p = 0.003) were found to be independent risk factors for treatment failure. The gene discussed is AICDA; the disease is diabetes mellitus.