We defined “non-IgE-mediated food allergic patients” as those who had gastrointestinal symptoms (diarrhea, vomiting, hematochezia, constipation), and/or cutaneous (eczema) and negative serum IgE to casein and whey protein and were then treated with hydrolyzed cow’s milk formula [6]. The gene discussed is IGHE; the disease is Hematochezia.