While the immediate symptoms of immunoglobulin E (IgE) mediated CMA are readily recognized, the diagnosis of non-IgE mediated CMA can pose a challenge due to the delayed onset of symptoms and overlap with other common pediatric manifestations of functional gastrointestinal disorders such as infantile colic, gastroesophageal reflux (disease) and even infections, particularly in the first months of life [1,2,6]. This evidence concerns the gene IGHE and digestive system disorder.