Additionally, identified pathways (Supplementary Materials Tables S1–S3; absolute FC ≥ 1.5, p-value < 0.05) included PI3K, ERBB2/HER2, ERBB-4, PLK1, TP53, and FGFR-related pathways, further highlighting the involvement of tumor suppressor genes and cancer-related pathways in CRC development, following the exposure to the food additive E171 [64,65]. The gene discussed is PLK1; the disease is cancer.