PIK3R6 and cancer: When the authors compared the DEGs that were downregulated at the ZnSO4 LC10 relative to at the ZnO NP LC10, they found cancer cell differentiation; endocytic transport and genes such as the epidermal growth factor receptor (EGFR), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), and phosphoinositide-3-kinase regulatory subunit 6 (PIK3R6) genes were upregulated in ZnO.