PLOD1 and precocious puberty: Although the most important parameter for the diagnosis of precocious puberty is the elevation of the LH value (baseline or after stimulation with GnRH analogues), it is described that pelvic ultrasound is a useful component in the differentiation with precocious thelarche, in which the consensus reports cutoff values between 1.0 and 3.0 mL of ovarian volume as a diagnostic criterion for precocious puberty [14].