In terms of biochemical parameters, both chronotypes had significant reduction in insulin (MD: −3.2, 95% CI: −4.5, −1.8, p < 0.001), insulin resistance marker-HOMA-IR [MD: −0.7, 95% CI: −1.1, −0.4, p < 0.001], triglyceride (MD: −0.1, 95% CI: −0.2, −0.01, p = 0.029), HDL-C (MD: −0.04, 95% CI: −0.1, −0.01, p = 0.024) and uric acid level (MD: −0.01, 95% CI: −0.02, −0.001, p = 0.028). The gene discussed is INS; the disease is Insulin resistance.