INS and type 2 diabetes mellitus: In this light, the work published by Khunti et al., a retrospective study of a cohort of over 81,000 people with type 2 diabetes, showed that, in patients treated with one, two, or three oral antidiabetic drugs, time to the intensification of treatment with an additional oral agent or insulin was 7.2 years, pointing to significant clinical inertia [14].