Patients affected by FAP (<1% cases of CRC), an autosomal dominant disease, inherit a germline mutation on the APC allele and precancerous lesions develop when the second allele acquires further genotoxic damage, becoming mutated or deleted, since APC represents a tumor-suppressor protein acting as an antagonist of the WNT-signaling pathway [41]. Here, APC is linked to colorectal carcinoma.