RYR2 and catecholaminergic polymorphic ventricular tachycardia: CPVT is an inherited disorder, linked to missense mutations of RyR2 (CPVT-1) (or other ECC proteins, including the SR Ca2+ buffer- and RyR-accessory protein calsequestrin (CPVT-2), CaM, Triadin, and the trans-2,3-enoyl-CoA reductase-like gene (TECRL)) [63,64].