MLH1 and colonic neoplasm: After patient file verification and proofreading, this patient had two distinct metachronous primary colon cancers, a dMMR/MSI, BRAF-mutated and hypermethylated MLH1 promoter, right colon cancer in 2005, and in 2003 a pMMR/MSS, BRAF wild-type, left-sided colon cancer stage II treated by surgery (Figure 2).