The anti-inflammatory role of α7 nAChR has been reported in several cell types such as human monocytes, macrophages, microglia, astrocytes, and disease animal models or patients with sepsis, rheumatoid arthritis, pancreatitis, and neuronal disorders including brain ischemia, AD, and PD [17,31,35,36,37,38,39]. This evidence concerns the gene CHRNA7 and Parkinson disease.