This fusion is caused by a translocation event involving intron 3 or 8 of PTPRZ and intron 1 of MET, is found in about 14% of secondary glioblastomas (i.e., astrocytoma, IDH mutant, WHO grade 4), and causes the activation of MET signaling [52]. This evidence concerns the gene MET and astrocytoma (excluding glioblastoma).