PRODH and 22q11.2 deletion syndrome: According to a recent transcriptome analysis of isolated astrocytes [146,148,170] contain all the genes deleted in 22q11DS to some extent or another, and PRODH seems to be one among the 30 genes that are highly expressed by astrocytes [146,148,170], thus suggesting that the PRODH enzyme plays an important role in regulating some astroglial functions.