PCDH8 and 22q11.2 deletion syndrome: Interestingly, it has been reported that disturbances in Pcdh8 are closely associated with autistic-like symptoms [95], a clinical feature that is frequently observed in 22q11DS patients [96] and alterations in the expression of Ywhaz and other members of the 14-3-3 family have been identified in the PFC and cerebellum of schizophrenic patients [97].