COMT and 22q11.2 deletion syndrome: Intriguingly, nine of the many genes deleted in 22q11DS can induce mitochondrial homeostasis disorders (COMT, UFD1L, DGCR8, MRPL40, PRODH, SLC25A1, TXNRD2, T10, and ZDHHC8), but the first three may have no more than an indirect effect on mitochondrial function, and only the last six encode mitochondrial proteins [101].