Intriguingly, nine of the many genes deleted in 22q11DS can induce mitochondrial homeostasis disorders (COMT, UFD1L, DGCR8, MRPL40, PRODH, SLC25A1, TXNRD2, T10, and ZDHHC8), but the first three may have no more than an indirect effect on mitochondrial function, and only the last six encode mitochondrial proteins [101]. Here, SLC25A1 is linked to 22q11.2 deletion syndrome.