As previously mentioned, ZDHHC8 encodes a mitochondrial palmitoyl transferase enzyme that is involved in regulating the cell localisation of target proteins [109] and a reduction in its expression reduces the strength of synaptic connections and impairs terminal arborisation in the hippocampus-PFC circuit of a mice model of 22q11DS [65]. The gene discussed is ZDHHC8; the disease is 22q11.2 deletion syndrome.