Most of the synaptic dysfunctions observed in these ZDHHC8-deficient mice are also present in the Df(16)A+/− mice model of 22q11DS carrying the 1.3 MB microdeletion in the mouse locus that is in synteny with the human 22q11.1 locus encompassing 27 genes [62]. This evidence concerns the gene ZDHHC8 and 22q11.2 deletion syndrome.