This finding further broadened the implication for phosphorylation of Nav1.6 in the context of neural plasticity and could aid in the development of novel therapies for brain disorders (Alzheimer’s, Parkinson’s, Huntington’s, etc.)associated with either upregulation of GSK3β or Nav1.6 activity [115,116,117,118]. This evidence concerns the gene SCN8A and Parkinsonism.