ABCB1 and cancer: In silico docking studies have revealed a high score of interaction for kaempferol with multidrug resistance protein-1 (MDR-1), and this interaction was probably the basis of the major cytotoxic effect observed in N1S1 and HepG2 cell lines when a combination of oxaliplatin, at sub-lethal concentration (2.5 μM), and kaempferol (2.5 μM), were used, highlighting an important field of application against cancer chemoresistance and dose toxicity [100].