PTGS2 and colorectal cancer: For example, a microarray dataset of 17 human colorectal cancer tissues and 17 matched normal tissues were examined for differential gene expression, and among these, four potential gene derived proteins (prostaglandin-endoperoxide synthase 2 -PTGS2, nuclear receptor subfamily 3 -NR3- C2 and CA2, as well as MMP-1) showing a high score of interaction with kaempferol were identified by molecular docking, but the authors did not validate the results by in vitro or in vivo studies [117].