In the landscape of the genetic heterogeneity of colon cancer cell lines, in HT-29 and SW480 that have the TP53 mutant gene [108], kaempferol induced apoptosis in a dose-dependent manner (0–60 μM) by decreasing phosphorylated AKT levels that corresponded to the activation of different proteins involved in intrinsic apoptosis. Here, AKT1 is linked to malignant colon neoplasm.