In the study of Riahi-Chebbi et al., the authors developed a colon cancer cell line resistant to 5-fluorouracil, LS174-R characterized by increased expression of ATP-binding cassette (ABC) transporters, an EMT phenotype and high levels of phosphorylated ERK1/ERK2, p38 and AKT. The gene discussed is AKT1; the disease is malignant colon neoplasm.