On the other hand, the expressions of all missense variants of TP53 in PDAC cell lines was higher than in the control, and it has been reported that some specific point mutations inactivate TP53 (p.Arg175, p.Gly245, p. Arg248, p.Arg249, p.Arg273, and p.Arg282) and confer an advantage in tumor growth [47,48]. The gene discussed is TP53; the disease is neoplasm.