HPGDS and tick-borne encephalitis: However, in the plasma of TBE patients, 4-HNE–protein adducts were created more significantly on proteins such as: glutathione S-transferase (GSH transferase), angiopoietin-4 (ANGPT4), clathrin, PDIA3, actinin-4, and peroxiredoxin-5 (PRDX5).