The parallel upregulation of ANXA3 in TBE/TBE+LD patients carries an increased risk of growth of the neutrophil–lymphocyte ratio, infiltrating all body tissues [43], the migration of which is regulated by actin-binding ACTN1, whose expression is also increased in TBE/TBE+LD plasma patients. The gene discussed is ACTN1; the disease is tick-borne encephalitis.