Figure 2D revealed both CE48T and KYSE70 CCRT resistance cells, the intensity of E-cadherin staining (green color) was obviously decreased when compared to parental cells. Moreover, the location of E-cadherin in cell surface was reduced, indicating the intercellular junctions were impaired upon the loss of E-cadherin expression. Conclusively, these two independent CCRTR lines established the association of EMT status and acquired concurrent chemoradiotherapy resistance by showing ESCC tumor cells with mesenchymal feature harbor poor response to CCRT treatment. The gene discussed is CDH1; the disease is neoplasm.