Hypoxia-induced lncRNA RP11-390F4.3 [52], Wnt/β-catenin signaling [53], and IKK-2/IκBα/NF-κB pathway [54] in breast cancer can regulate multiple EMT regulators such as Snail, Twist1, and ZEB1/2 to promote tumor metastasis. The gene discussed is TWIST1; the disease is breast carcinoma.